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KMID : 0382320050250010001
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Environmental Mutagens and Carcinogens
2005 Volume.25 No. 1 p.1 ~ p.5
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Antimetastatic Effects of Capsaicin in Murine B16 Melanoma Cell Lines
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Hwang MS
Yum YN/Kang HI/Kim OH
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Abstract
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The present work was undertaken to evaluate the antimetastatic potential of capsaicin (8-methyl-N-vanillyl-6-nonenamide) by measuring its effects on matrix metalloproteinase activity, cell invasion and lung metastasis. Significant inhibition of matrix metalloproteinase-2 activity by capsaicin (100 μM) was detected by gelatin zymography. In vitro invasion assay showed capsaicin (50, 100 μM) reduced tumor cell invasion (28-40%). Capsaicin (i.p., 2.5 mg/kg) inhibited development of lung colonization (58%). These results suggest that capsaicin prevents metastasis in part through suppression of invasion of B16F10 melanoma cells by inhibiting matrix metalloproteinase-2 responsible for degradation of extracellular matrix.
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